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| 高频刺激丘脑底核对帕金森病大鼠模型纹状体神经元放电的影响 | |
| 作者姓名： | Gu PF Gao DM Shang Y |
| 作者单位： | 1. 沈阳药科大学药理研究室,辽宁,沈阳,110015 2. 锦州医学院生理教研室,辽宁,锦州,121001 3. 解放军第463医院麻醉科,辽宁,沈阳,110042 |
| 摘 要： | 目的:观察高频刺激丘脑底核(STN)对帕金森病(PD)大鼠模型纹状体 (STR)神经元自发放电的影响.方法:应用6-羟基多巴胺(6-OHDA)制备偏侧PD大鼠模型,丘脑底核区插入刺激电极进行高频刺激,采用细胞外单位记录的方法观察STR神经元自发放电频率的改变.结果:正常大鼠刺激后STR神经元反应主要以兴奋型反应为主, PD大鼠STR神经元反应主要以兴奋抑制型为主,且随着刺激时间的延长,抑制持续时间逐渐增加,持续时间与刺激时间密切相关(r=0.94).结论:刺激STN可使PD大鼠纹状体的异常放电得到改善,提示高频电刺激STN可作为一种有效的治疗PD的方法. |
| 关 键 词： | 帕金森病 丘脑底核 纹状体 高频刺激 自发放电 |
| 文章编号： | 1000-6834(2004)01-0083-05 |
| 修稿时间： | 2003年1月2日 |
Effect of high-frequency stimulation to subthalamic nucleus on STR neuronal firing rates in Parkinson disease rats |
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| Gu PF,Gao DM,Shang Y.Effect of high-frequency stimulation to subthalamic nucleus on STR neuronal firing rates in Parkinson disease rats[J].Chinese Journal of Applied Physiology,2004,20(1):83-87. | |
| Authors: | Gu Pei-Fei Gao Dong-Ming Shang Yu |
| Institution: | GU Pei-fei 1,GAO Dong-ming 2,SHANG Yu 3 |
| Abstract: | Aim: To observe the change of STR neuronal firing rates with high-frequence stimulation of subthalamic nucleus in PD rats. Methods: A model of Parkinson's disease was induced by unilateral administration of 6-hydroxydopamine into right substantia nigra in rats.After the high-frequence stimulation to STN,the spontaneous firing rates of STR on normal and PD rats were recorded by using extracelluar recordings. Results: Stimulation caused a direct excited effect of STR neurons in normal rats whereas a excited and inhibited effect in PD rats.The inhibited effect was correlated with the stimulation period(r=0.94). Conclusion: Stimulation to STN may inhibit the spontaneous firing rates of STR neurons in PD rats. These results also give some clues that high-frequence stimulation to STN may be a effective therapy to the clinical treatment of Parkinson's disease. |
| Keywords: | Parkinson's disease subthalamic nucleus striatum high-frequence stimulation firing |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |