| 清醒羊低氧性肺动脉高压及逆转中肺血管对外源性血小板活化因子的反应 |
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| 引用本文： | 马传桃.清醒羊低氧性肺动脉高压及逆转中肺血管对外源性血小板活化因子的反应[J].中国应用生理学杂志,1995,11(1):30-34. |
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| 作者姓名： | 马传桃 |
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| 作者单位： | 湖南医科大学心血管生理研究室 |
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| 摘 要： | 本实验复制了清醒羊低氧性肺动脉高压（ＨＰＨ）及其逆转模型，动态观察了在ＨＰＨ发生、发展及逆转中肺、体循环对外源性血小板活化因子（ＰＡＦ）的反应。结果表明：（１）ＰＡＦ对清醒羊常氧期、ＨＰＨ及ＨＰＨ逆转期均为一强效应肺血管收缩剂，且呈剂量依赖性；（２）ＨＰＨ期：ＰＡＦ对肺血管加压反应增值百分离较常氧期及ＨＰＨ逆转期低；（３）ＰＡＦ对三期体动脉压、心率无明显影响，却能降低各期心输出量。
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| 关 键 词： | 血小板活化因子 肺血管 低氧性 肺动脉高压 |
PULMONARY VASCULAR RESPONSE TO EXOGENOUS PLATELET ACTIVATING FACTOR
IN CONSCIOUS SHEEP WITH HYPOXIC PULMONARY HYPERTENSION AND ITS
REGRESSION |
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| Ma Chuantao.PULMONARY VASCULAR RESPONSE TO EXOGENOUS PLATELET ACTIVATING FACTOR
IN CONSCIOUS SHEEP WITH HYPOXIC PULMONARY HYPERTENSION AND ITS
REGRESSION[J].Chinese Journal of Applied Physiology,1995,11(1):30-34. |
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| Authors: | Ma Chuantao |
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| Abstract: | A model
of hypoxic pulmonary hypertension(HPH)and its regression was made in
10 con-scious sheep.Hemodynamic response to exogenous platelet
activating factor(PAF) was studiedin these sheep.The results were as
follows:(1) PAF was a potent pulmonary vasoconstrictor andits effect
was dose-dependent;(2) In the hypoxic period,pulmonary vascular
pressor responsewas induced bY PAF,but the value of % increase in PAP
was less than in normoxic period andregression period;(3) PAF did not
change systemic arterial pressure and heart rate,but de-creased
cardiac output during the three periods. |
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| Keywords: | platelet activating factor pulmonary vessel hypoxic pulmonary hypertension hemodynamics sheep |
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