| 低氧对新生大鼠下丘脑促肾上腺皮质激素释放激素发育的影响 |
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| 引用本文： | 杨生妹,杜继曾,李良成.低氧对新生大鼠下丘脑促肾上腺皮质激素释放激素发育的影响[J].中国应用生理学杂志,1996(4). |
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| 作者姓名： | 杨生妹 杜继曾 李良成 |
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| 作者单位： | 中国科学院西北高原生物研究所 |
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| 基金项目： | 中国科学院上海生理所低氧生理开放实验室资肋 |
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| 摘 要： | 本文研究模拟高原低氧下新生和胚胎大鼠发育时，下丘脑内促肾上腺皮质激素（ＣＲＦ）及垂体环磷酸腺苷（ｃＡＭＰ）水平的变化。结果表明：５ｋｍ海拔高度抑制下丘脑ＣＲＦ的发育，当发育至２５天和３０天时，ＣＲＦ含量分别为对照组的６４．８％和５７．９％。此时，体重分别为４７．８％和５２．９％。３０天时，ｃＡＭＰ为２０．８％。本研究还显示，在７ｋｍ海拔高度，已怀孕大鼠难以完成正常的妊娠和胎儿发育过程，５ｋｍ海拔高度暴露１７天时，胚胎脑内ＣＲＦ含量高于对照。
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| 关 键 词： | 低氧发育 促肾上腺皮质激素释放激素 环磷酸腺苷 新生大鼠 胚胎大鼠 |
EFFECTOFHYPOXIAONTHEDEVELOPMENTOFHYPOTHALAMICCORTICOTROPIN RELEASINGFACTOROFNEONATALRATS |
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| YangShengmei,DuJizeng,LiLiangcheng.EFFECTOFHYPOXIAONTHEDEVELOPMENTOFHYPOTHALAMICCORTICOTROPIN RELEASINGFACTOROFNEONATALRATS[J].Chinese Journal of Applied Physiology,1996(4). |
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| Authors: | YangShengmei DuJizeng LiLiangcheng |
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| Abstract: | Changesofthedevelopmentofhypothalamiccorticotropin releasingfactor(CRF)andpituitarycAMPofneonatalandfetalratsexposedtosimulatedaltitudehypoxiainhypobaricchamberwerestud iedtheresultsshowedthatwhentheanimalswereexposedto5kmaltitudefor10,15,20,25and30days,theirbodyweightincreasedwithagebutmoreslowlythancontrolgroup(2.3km).Thehy pothalamicCRFwasalsodevelopedwithageandstillowerthancontrol,especialyon30and35days(exposedfor25and30days),just64.8%and57.9%ofthecontrolgroup.Meanwhile,thepituitarycAMPwashigherbutnotsignificantthancontrolwhenexposedfor20and25days,anddecreasedrapidlyfor30days,only20.8%ofthecontrolgroup.Itwasalsofoundthatpregnantratscouldnotcompletetheirpregnancy,thus,theirfetuscouldnotdevelopwelat7kmaltitude.TheCRFof20 day oldfetus(exposedfor17days)washigherthancontrolgroupat5kmaltitude.ThedevelopmentofhypothalamicCRFwasmarkedlyinhibitedwhenneonatalratswereexposedto5kmaltitudefor25and30days,suggestingthatthismaybethekeystageofdevelopmentandhypoxiacouldnotprovideenoughoxygenandenergyfortheirmetabolism. |
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| Keywords: | hypoxiadevelopment corticotropin releasingfactor cyclicadenosinemonophosphate neonatalrats fetalrats |
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