| 联合补充维生素B_1、B_2、PP对急性低氧暴露小鼠物质代谢的改善作用 |
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| 作者姓名： | Liu J Guo CJ Wu JQ Yang JJ Wei JY Gao WN |
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| 作者单位： | 卫生学环境医学研究所;总后军需装备研究所; |
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| 基金项目： | 国家自然科学基金资助项目(30872097) |
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| 摘 要： | 目的：观察联合补充维生素B1、B2、PP对急性低氧暴露小鼠碳水化合物、脂类、蛋白质以及能量代谢的改善作用。方法：将雄性昆明小鼠随机分为正常对照组、低氧对照组2、倍、4倍及8倍维生素B1、B2、PP补充组,各组动物以相应饲料喂养2周后,除正常对照组外,其他各组均以减压缺氧方式模拟6 000 m高度停留8 h,分析血糖、肝糖原、血清丙酮酸、血乳酸、血清尿素氮、血清游离脂肪酸和β-羟丁酸、全血三磷酸腺苷（ATP）含量的变化。结果：急性低氧暴露后,小鼠血糖、肝糖原、血清丙酮酸、血乳酸、血清游离脂肪酸,β-羟丁酸,尿素氮含量均显著上升（P〈0.05）,全血ATP含量下降;补充维生素B1、B2、PP对急性低氧导致的以上生化指标的变化有一定的改善作用。结论：急性低氧暴露后,机体三大营养素代谢发生改变,补充维生素B1、B2、PP可以在一定程度上缓解急性低氧对机体带来的代谢变化,4倍补充剂量效果较好。
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| 关 键 词： | 维生素B1、B2、PP 急性低氧 小鼠 |
Improvement effect of vitamins B1, B2 and PP supplementation on substance metabolism of mice exposed to acute hypoxia |
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| Liu J,Guo CJ,Wu JQ,Yang JJ,Wei JY,Gao WN.Improvement effect of vitamins B1, B2 and PP supplementation on substance metabolism of mice exposed to acute hypoxia[J].Chinese Journal of Applied Physiology,2011,27(2):215-218. |
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| Authors: | Liu Jin Guo Chang-Jiang Wu Jian-Quan Yang Ji-Jun Wei Jing-Yu Gao Wei-Na |
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| Institution: | LIU Jin1,2,GUO Chang-jiang1,WU Jian-quan1,YANG Ji-jun1,WEI Jing-yu1,GAO Wei-na1(1.Institute of Health and Environmental Medicine,Tianjin 300050,2.The Quartermaster Research Institute of the General Logistics Department,Beijing 100010,China) |
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| Abstract: | Objective:To explore the improvement effect of vitamins B1,B2,PP supplementation to the metabolism changes of carbohydrates,lipids,protein and energy in mice exposed to acute hypoxia.Methods:Fifty male Kunming mice were randomly divided into normal,acute hypoxia,acute hypoxia plus 2 times,4 times and 8 times vitamins B1,B2,PP supplemented groups.All mice were fed corresponding diets for two weeks and then except the normal group were exposed to a simulated altitude of 6 000 meters for 8 hours.The changes of... |
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| Keywords: | vitamins B1 B2 PP acute hypoxia mice |
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