| 慢性应激对大鼠学习记忆能力和海马LTP的影响 |
| |
| 引用本文： | 马强,王静,杨志华,刘洪涛,晁福寰.慢性应激对大鼠学习记忆能力和海马LTP的影响[J].中国应用生理学杂志,2000,16(4):318-320. |
| |
| 作者姓名： | 马强 王静 杨志华 刘洪涛 晁福寰 |
| |
| 作者单位： | 军事医学科学院卫生学环境医学研究所,天津,300050 |
| |
| 摘 要： | 目的和方法：本研究采用一种多因素的２１ｄ慢性应激动物模型，以Ｙ迷宫和ＬＴＰ为指标，探讨慢性应激对运动学习记忆能力和海马神经突触可塑性的影响。结果：长期慢性应激使大鼠空间学习记忆能力下降，而且，使中枢海马齿状回ＬＴＰ的诱生受到抑制。结论：慢性应激可能使大鼠海马齿状回神经突触可塑性降低，并进一步影响到学习记忆的功能。
|
| 关 键 词： | 慢性应激 海马 长时程增强 学习记忆 LTP |
| 修稿时间： | 1999-08-02 |
EFFECTS OF CHRONIC STRESS ON THE LEARNING AND MEMORY ABILITY AND HIPPOCAMPAL LTP IN RATS |
| |
| MA Qiang,WANG Jing,YANG Zhi-hua,LIV Hong-tao,CHAO Fu-huan.EFFECTS OF CHRONIC STRESS ON THE LEARNING AND MEMORY ABILITY AND HIPPOCAMPAL LTP IN RATS[J].Chinese Journal of Applied Physiology,2000,16(4):318-320. |
| |
| Authors: | MA Qiang WANG Jing YANG Zhi-hua LIV Hong-tao CHAO Fu-huan |
| |
| Institution: | Institute of Health and Environmental Medicine, Tianjin 300050. |
| |
| Abstract: | Aim and Methods: A chronic stress model in 21 days with multi stressors was applied to question the effects of stress on the learning and memory ability and the hippocampal neuronal synaptic plasticity in rats, using the Y maze test and LTP electrophysiological recording in vivo. Results: The impairment of spatial learning and memory ability and an obvious suppression in LTP in hippocampal dentate gyrus was observed in stress group after chronic stress. Conclusion: The hippocampal synaptic plasticity may be decreased by the chronic stress. And then, the learning and memory ability may also be impaired consequently. |
| |
| Keywords: | chronic stress hipocampus long term potentiation(LTP) learning and memory |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
