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淋巴液的抗休克作用
引用本文:牛春雨,张静.淋巴液的抗休克作用[J].中国应用生理学杂志,1999,15(1):72-76.
作者姓名:牛春雨  张静
作者单位:张家口医学院病理生理教研室
摘    要:目的和方法:应用显微电视录象设备和活体大鼠肠系膜微循环观察技术,观察胸导管淋巴液对重症失血性休克大鼠血压和微循环障碍的影响,以探讨淋巴液的抗休克作用及其机制。结果:淋巴液治疗组大鼠存活时间(703h)显著高于白蛋白对照组(205h)。治疗组输入胸导管淋巴液后血压显著回升,血液流态改善,有效地解除肠系膜细动、静脉和微淋巴管(ML)静态口径的病理性收缩,ML收缩分数、总收缩活性指数及淋巴管动力学指数恢复正常,而白蛋白对照组的微血管口径及三个ML收缩性指数仍处于休克时水平,且明显低于治疗组(P<0.01)。结论:淋巴液具有良好的抗休克作用,其机制可能与显著改善休克时的微循环障碍和提升血压有关

关 键 词:淋巴液  失血性休克  微循环

THE ANTAGONISTIC EFFECT OF LYMPH ON SHOCK IN RAT
Niu Chunyu,Zhang Jing,Yao Tong,et al..THE ANTAGONISTIC EFFECT OF LYMPH ON SHOCK IN RAT[J].Chinese Journal of Applied Physiology,1999,15(1):72-76.
Authors:Niu Chunyu  Zhang Jing  Yao Tong  
Abstract:Aim and Methods:To observe the effect of thoracic duct lymph on the blood pressure and obstruction of microcirculation in rat with irreversible hemorrhagic shock by a microscope with TV recorder and the technique of vital observation on mesenteric microcirculation in rats.Results:The average survival time was obviously prolonged (7.03 h) in the thoracic duct lymph treated group, and the lymph was able to make blood pressure in shock rise significantly compared with albumin control group (2.05 h). After the administration of thoracic duct lymph in the treated group, the pathological narrow and spasm of mesenteric micro vessles and micro lymphatics(ML) in shock was removed apparently; the mesenteric micro vessles blood flow condition and its speed were improved progressively, thus they return back to the normal condition; ML contractile fraction,overall lymphatic contractile activity and lymphatic dynamics restored.In albumin control group,the diameter in micro vessels and ML contractility were still in lower level as in shock and ever lower than treated group. But there was no statistical difference between two groups in ML spontaneous contraction frequency. Conclusion:Lymph may improve the obatruction of microcirculation in shock and have better antagonistic role on hemorrhagic shock.
Keywords:lymph  hemorrhagic shock  microcirculation  
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