| 电针对庆大霉素耳毒性的预防作用 |
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| 引用本文： | 康颂建,史永芝.电针对庆大霉素耳毒性的预防作用[J].中国应用生理学杂志,1999,15(3):277-280. |
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| 作者姓名： | 康颂建 史永芝 |
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| 作者单位： | 泰山医学院生理教研室!泰安271000(康颂建，史献君，李亚鲁)，上海中医药大学(曾兆麟)，泰山医学院第一教学医院(史永芝) |
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| 基金项目： | 国家自然科学基金!(No .3 9470 86 9) |
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| 摘 要： | 目的和方法 :本实验用耳廓反射 (PR)、脑干听觉诱发电位 (BAEP)、组织化学方法 ,观察电针疗法对豚鼠庆大霉素 (GE)耳毒性的防治作用 ,并探讨其机制。结果 :电针疗法能降低GE引起的PR阈值和BAEP反应阈的上移幅度及BAEP波峰潜伏期和波峰间期的延长 ,能维持毛细胞溶酶体的完整 ,防止毛细胞的自溶性破坏。结论 :电针疗法有对抗GE耳毒性作用。维持耳蜗毛细胞内溶酶体完整 ,防止溶酶体内水解酶的逸出而发生细胞自溶 ,可能是电针疗法的作用机制之一。
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| 关 键 词： | 电针 庆大霉素 耳毒性 酸性磷酸酶 |
PREVENTIVE EFFECT OF ELECTROACUPUNCTURE ON OTOTOXICITY INDUCED BY GENTAMYCIN IN GUINEA PIGS |
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| Kang Songjian,Zeng Zhaolin,Shi Xianjun,et al..PREVENTIVE EFFECT OF ELECTROACUPUNCTURE ON OTOTOXICITY INDUCED BY GENTAMYCIN IN GUINEA PIGS[J].Chinese Journal of Applied Physiology,1999,15(3):277-280. |
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| Authors: | Kang Songjian Zeng Zhaolin Shi Xianjun |
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| Abstract: | Aim and Methods: Preventive effect of electroacupuncture on ototoxicity induced by gentamycin(GE) was observed with Preyer's reflex(PR), brainstem auditory evoked potential(BAEP) and histochemistry method in guinea pigs and its mechanism was explored. Results: Electroacupuncture could lower the amplitude of PR threshold shift and BAEP reaction threshold shift and prolonga ting of latencies and interpeak intervals of BAEP waves. It could keep of lysosomeintact in the cochlear hair cells, and prevent injury of the cochlear hair cells. Conclusion: Both maintaining of lysosome completion intact in the cochlear hair cells and prevention of hair cells autolysis induced by hydrolase in the lysosome may be a possible meshanism of action of electroacupuncture therapy. |
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| Keywords: | electroacupuncture therapy gentamycin ototoxicity acid phosphatase |
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