模拟高原低氧对新生大鼠肾上腺皮质功能发育的影晌

本文探讨新生大鼠肾上腺皮质对高原低氧的应答及模拟高原低氧对其功能发育的影响。结果表明，当不同日龄大鼠暴露于５ｋｍ及７ｋｍ海拔２４ｈ，７ｄ、１４ｄ龄大鼠肾上腺皮质无明显应答反应。２１ｄ及２８ｄ龄大鼠肾上腺皮质酮水平随海拔增高而增加，血浆皮质酮表现为抑制作用。当１ｄ龄新生大鼠在５ｋｍ海拔高度发育３ｄ和７ｄ，其肾上腺皮质功能无异于正常发育大鼠；但发育１４ｄ、２１ｄ及２８ｄ，其血液及肾上腺中皮质酮含量均明显低于对照组，肾上腺皮质功能发育严重受抑

THE EFFECT OF THE SIMULATED ALTITUDE HYPOXIA ON THE DEVELOPMENT OF ADRENAL CORTEX FUNCTION OF NEONATAL RATS

The response of the corticosterone in neonatal rats to simulated altitude hypoxia and the development of their adrenal cortex function at 5 km altitude were investgated. When exposed to 5 km and 7 km altitude for 24 h, the content of adrenal cortex and plasmic corticosterone of 7 d(7 days old) rats did not change. But the plasmic corticosterone decreased in 14 d rats at 7 km altitude (20. 33% of control). The plasmic corticosterone of 21 d rats also reduced at 7 km (5% of control), and their adrenal gland corticosterone increased significantly at 5 km and 7 km(144% and 167% of control, respectively). For 28 d rats, their plasmic corticosterone stopped to decrease under hypoxia, and the content of adrenal gland corticosterone increased at 7 km (164% of control), suggesting that in the neonatal rat before 28 d old the response of the biosyntheses of adrenal corticosterone to hypoxia was much sensitive than do the release of corticosterone. When 1 day old neonatal rats developed at 5 km altitude for 3 and 7 d, the development of the function of their adrenal corticosterone was not influenced. But when developed for 14, 21 and 28 d, the content of plasmic and adrenal gland corticosterone decreased significantly, and the development of the function of adrenal gland was inhibited severely.