中老年男性患者血脂代谢特点及与年龄等因素的相关分析

目的:探讨中老年男性患者血脂代谢特点及与年龄等因素的相关性。方法:资料来自2006年6月于我院干部门诊进行健康查体的1603例中老年男性患者(排除正在服用降脂药物的患者),采用全自动生化分析仪对血清总胆固醇(TC)、血清甘油三酯(TG)、血清低密度脂蛋白胆固醇(LDL-c)、血清高密度脂蛋白胆固醇(HDL-c)、空腹血糖(FBG)、血肌酐(Cr)及血尿酸(UA)等指标进行测定,同时记录身高、体重及血压等基本资料。结果:入选患者血脂异常总检出率为56.27%,其中TC、TG、HDL-c及LDL-c异常检出率分别为36.74%、28.20%、10.79%及6.92%,以TC、TG异常为主。与50~59岁组相比,80岁以上高龄老年组TG异常及HDL-c异常检出率显著降低,TC及TG水平显著降低,HDL-c水平显著升高(P<0.05)。在校正BMI、SBP、DBP、UA、FBG及CCr等危险因素影响后的多元线性回归分析发现,年龄每升高10岁,TC、TG分别降低约0.097 mmol/L及0.087 mmol/L,HDL-c升高约0.113 mmol/L。结论:中老年男性患者血脂异常以高TC和高TG为主,TC、TG与年龄呈负相关,HDL-c与年龄呈正相关,需针对高龄老年患者血脂代谢特点进行合理调脂治疗。

The metabolism characteristics of blood lipids and the correlation analysis of blood lipids and related factors such as age in the middle-aged and elderly men

Objective: To investigate the relationship between the blood lipids and risk factors such as age in middle-aged and elderly men.Methods: 1603 men aged over 50 years old who took health examinations in June 2006 in the Chinese PLA General hospital were taken into the study.The total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-c),high density lipoprotein cholesterol(HDL-c),fasting serum glucose(FBG),serum creatinine(Cr) and blood uric acid(UA) were detected,and the clinical data such as age,body height,body weight and blood pressure were recorded.Results: ①The detection rates of hyperlipidemia,abnormal TC,abnormal TG,abnormal HDL-c and abnormal LDL-c were 56.27%,36.74%,28.20%,10.79% and 6.92% respectively,and the TC and/or TG abnormality were the majority.②Compared with the 50~59 years old group,the elderly men aged over 80 years old had lower detection rates of abnormal TC and abnormal HDL-c,lower levels of TC and TG and higher levels of HDL-c(P<0.05).After adjusting for BMI,SBP,DBP,UA,FBG and CCr,the multiple regression analysis showed that the levels of TC and TG decreased by 0.097 mmol/L and 0.087 mmol/L respectively every 10 years older,while the level of HDL-c increased by 0.113 mmol/L.Conclusion: The study showed that the majority types of hyperlipidemia in middle-aged and elderly men were abnormal TC and abnormal TG.The levels of TC,TG were correlated with age positively and the HDL-c was negatively correlated with age.The blood lipids metabolism characteristics of elderly men aged over 80 years old should be considered before the treatment of hyperlipidemia.