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南瓜多糖对糖尿病大鼠血糖和血脂的影响
作者姓名:Liu Y  Jin H  Xu ZQ  Nan WK  Wang T  Cheng YY
作者单位:军事医学科学院卫生学环境医学研究所,天津,300050
摘    要:目的:研究南瓜多糖对糖尿病大鼠血糖和血脂的影响。方法:Wistar大鼠腹腔注射四氧嘧啶后。将成模的糖尿病大鼠根据血糖和体重随机分为糖尿病组、消渴丸组和南瓜多糖组,同时设立正常对照组,并分别给予蒸馏水、消渴丸和南瓜多糖灌胃,每周测量体重一次,四周后测定空腹血糖、血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白和游离脂肪酸的含量。结果:糖尿病组大鼠体重下降,血糖显著升高,甘油三酯、总胆固醇、低密度脂蛋白和游离脂肪酸含量显著增加,而高密度脂蛋白含量显著降低;补充南瓜多糖和消渴丸后,体重逐渐增加,血糖显著下降,总胆固醇、甘油三酯、低密度脂蛋白和游离脂肪酸含量显著降低,高密度脂蛋白含量显著升高,并且南瓜多糖的降糖降脂效果优于消渴丸。结论:南瓜多糖能增加体重,降低糖尿病大鼠血糖、血脂,对糖尿病及其并发症有一定的作用。

关 键 词:南瓜多糖  糖尿病  血糖  血脂
文章编号:1000-6834(2006)03-0358-04
收稿时间:2006-01-20
修稿时间:2006-01-202006-03-06

Effects of pumpkin polysaccharides on blood glucose and blood lipids in diabetic rats
Liu Y,Jin H,Xu ZQ,Nan WK,Wang T,Cheng YY.Effects of pumpkin polysaccharides on blood glucose and blood lipids in diabetic rats[J].Chinese Journal of Applied Physiology,2006,22(3):358-361.
Authors:Liu Ying  Jin Hong  Xu Zhi-qin  Nan Wen-kao  Wang Tao  Cheng Yi-yong
Institution:Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China
Abstract:Aim: To investigate the effects of pumpkin polysaccharides on blood glucose and lipids levels in diabetic rats.Methods: Diabetic rats induced by alloxan through intraperitoneal injection were randomly divided into three groups,diabetes,xiaoke pill and pumpkin polysaccharides group,according to weight and blood glucose level.And the normal control group was founded at the same time.The normal control group and diabetes group were lavaged with distilled water,other two groups were respectively lavaged with xiaoke pill or pumpkin polysaccharides.Weighed once a week,and analyzed fasting blood glucose,total cholesterol,triglyceride,high density lipoprotein,low density lipoprotein,and free fatty acid level in serum after 4 weeks.Results: In diabetes group,weight and high density lipoprotein level decreased,and fasting blood glucose,total cholesterol,triglyceride,low density lipoprotein,and free fatty acid level in serum increased significantly.But,all of the indexes changed oppositely in xiaoke pill group and pumpkin polysaccharides group,and effects of pumpkin polysaccharides were better.Conclusion: Pumpkin polysaccharides can increase the weight,decrease the blood glucose and lipids levels in diabetic rats,and have some good effects to diabetes and diabetes complications.
Keywords:pumpkin polysaccharides  diabetes  blood glucose  blood lipids
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