| 人胎肝细胞分泌的低分子抑瘤物对白血病细胞的抑制作用 |
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| 引用本文： | 吴祖泽,裴雪涛.人胎肝细胞分泌的低分子抑瘤物对白血病细胞的抑制作用[J].中国应用生理学杂志,1993,9(1):20-24. |
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| 作者姓名： | 吴祖泽 裴雪涛 |
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| 作者单位： | 北京放射医学研究所，北京放射医学研究所，北京放射医学研究所 北京 100850，北京 100850，北京 100850 |
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| 摘 要： | 本工作证明了在胎儿组织中存在一类低分子天然肿瘤抑制物,它是胎儿组织细胞生成和分泌的,对瘤株细胞和原代白血病细胞有选择性抑制作用。初发期或复发期急性非淋巴细胞白血病患者的骨髓在体外液体培养条件下与肝细胞上清及其甲醇提取物共同孵育4d,可使所有病例的骨髓AML—CFU降低到不可检出的程度。因而,低分子天然抑瘤物是天然肿瘤免疫中的一个组成部分,它在肿瘤的诊断和治疗中有着深远的意义。
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| 关 键 词： | 白血病细胞 低分子天然抑瘤物 人胎肝细胞 |
SUPPRESSION OF LEUKEMIC CELL GROWTH IN VITRO BY A LOW MOLECULAR WEIGHT NATURAL TUMOR SUPPRESSOR PRODUCED BY HUMAN FETAL LIVER CELLS |
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| Wu Chutse,Pei Xuetao,Xue Huihua.SUPPRESSION OF LEUKEMIC CELL GROWTH IN VITRO BY A LOW MOLECULAR WEIGHT NATURAL TUMOR SUPPRESSOR PRODUCED BY HUMAN FETAL LIVER CELLS[J].Chinese Journal of Applied Physiology,1993,9(1):20-24. |
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| Authors: | Wu Chutse Pei Xuetao Xue Huihua |
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| Abstract: | A low molecular weight natural tumor suppressor substance (LMW-NTS) has been described previously. It is naturally produced and continuously released from fetal liver cells in vitro and expressed its selective suppression on the growth of HL-60 cells and primary leukemic cells (AML-CFU) rather than on that of human bone marrow CFU-GM. After cultivating the bone marrow of leukemia patients for 4 or 9 days in liquid medium containing LMW-NTS, the primary myeloid leukemic cells could be effectively eradicated. These facts support the existence of a low molecular weight tumor suppressor in embryonic tissue, which might be one of the humoral factors in protecting the oganism against the occurrence and development of cancer, ensuring the growth of embryo in a normal state. |
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| Keywords: | low molecular weight tumor suppressor HL-60 cells AML-CFU CFU-GM human fetal liver cells |
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