| 侧脑室注射促甲状腺激素释放激素对大鼠睡眠—觉醒的影响 |
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| 引用本文： | 朱国庆,？张惠秀.侧脑室注射促甲状腺激素释放激素对大鼠睡眠—觉醒的影响[J].中国应用生理学杂志,1993,9(2):143-146. |
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| 作者姓名： | 朱国庆 ？张惠秀 |
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| 作者单位： | 安徽医科大学睡眠障碍研究室，安徽医科大学睡眠障碍研究室，安徽医科大学睡眠障碍研究室，安徽医科大学睡眠障碍研究室，安徽医科大学睡眠障碍研究室 合肥 230032，合肥 230032，合肥 230032，合肥 230032，合肥 230032 |
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| 摘 要： | 采用多导睡眠描记术研究了例脑室注射促甲状腺激素释放激素(TRH)对正常大鼠和去甲状腺大鼠睡眠-觉醒的影响。在正常大鼠,TRH引起觉醒增加,浅慢波睡眠(SWS_1)、深慢波睡眠(SWS_2)和总睡眠时间(TST)均减少,异相睡眠(PS)消失,SWS_1、SWS_2和PS的潜伏期均显著延长,给药后立即产生效应并在1h内达高峰。去甲状腺对大鼠的睡眠-觉醒无明显影响,注射TRH后引起的效应与正常大鼠相似。结果提示TRH有促进大鼠觉醒的作用,对各睡眠时相均有抑制作用,其作用部位可能在下丘脑以外的中枢结构。
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| 关 键 词： | 促甲状腺激素释放激素 觉醒 睡眠 多导睡眠描记术 侧脑室 甲状腺 |
EFFECTS OF INTRACEREBROVENTRICULAR INJECTION OF THYROTROPIN-RELEASING HORMONE ON WAKEFULNESS AND SLEEP IN RATS |
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| Zhu Guoqing,Zhang Huixiu,Wang Min,Kong Xiudi,Zhang Jingxing.EFFECTS OF INTRACEREBROVENTRICULAR INJECTION OF THYROTROPIN-RELEASING HORMONE ON WAKEFULNESS AND SLEEP IN RATS[J].Chinese Journal of Applied Physiology,1993,9(2):143-146. |
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| Authors: | Zhu Guoqing Zhang Huixiu Wang Min Kong Xiudi Zhang Jingxing |
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| Abstract: | The study was undertaken using polysomnography to examine the effects of intracerebroventricular injection of thyrotropin-releasing hormone (TRH) on wakefulness (W) and sleep in normal and thyroprivic rats. In normal rats, TRH significantly increased the time of W, decreased light slow wave sleep (SWS1), deep slow wave sleep (SWS2) and total sleep time (TST), and abolished paradoxical sleep (PS) in the first hour after injection. TRH also lengthened the latencies of SWS1, SWS2 and PS. In thyroprivic rats, the changes induced by TRH were similar to those in normal rats. The data suggested that TRH could have a strong excitatory effects on central nervous system and inhibited various phases of sleep which was not mediated by hypothalamus, and thyroprivia could not affect sleep and wakefulness. |
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| Keywords: | thyrotropin- releasing hormone (TRH) first ventricle of brain wakefulness sleep polysomnography thyroid |
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