Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT‐A37 |
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Authors: | Hui Ding Jia‐Nan Wang Da‐Shan Zhang Zhong‐Jun Ma |
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Institution: | Institute of Marine Biology, Ocean College, Zhejiang University, Zhoushan, P. R. China |
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Abstract: | On the basis of the one strain–many compounds strategy, five compounds including two new holomycin derivatives 2 – 3 , two new cyclopropaneacetic acid derivatives 4 – 5 , together with one known compound holomycin ( 1 ) were isolated from a marine‐derived bacterium Streptomyces sp. DT‐A37. Their structures were elucidated using NMR and HR‐ESI‐MS analyses. All these compounds were evaluated for their antimicrobial activity, cytotoxic activity, and inhibitory activity against BRD4 protein. Compound 1 exhibited potent cytotoxicity against H1975 cells with IC50 value of 1 μm , and its minimal inhibitory concentration values against Escherichia coli and Staphylococcus aureus were both 64 μm . |
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Keywords: | Sulfur heterocycles Fatty acids Biological activities Streptomyces sp DT‐A37 OSMAC Strategy |
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