Pelliolatifolias A-D,Four Undescribed Compounds from Pellionia latifolia Boerl. and Their Nitric Oxide Production Inhibitory Activity |
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| Authors: | Tran Thi Thu Ha Nguyen Thi Cuc Bui Huu Tai Khuat Huu Trung Tran Dang Khanh Phan Van Kiem |
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| Institution: | 1. Institute of Forestry and Sustainable Development (IFS), Thai Nguyen University of Agriculture and Forestry, Thai, Nguyen City (TUAF), Vietnam;2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam;3. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam;4. Agricultural Genetic Institute, Pham Van Dong, Bac Tu Liem, Vietnam |
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| Abstract: | Four undescribed compounds ( 1 – 4 ) named pelliolatifolias A−D together with seven known compounds trans-clovamide ( 5 ), N-trans-caffeoyl-4-hydroxyphenylalanine methyl ester ( 6 ), N-trans-caffeoyl-3,4-dihydroxyphenylalanine methyl ester ( 7 ), luteolin 4’-O-β-D-glucopyrannoside ( 8 ), cis-syringin ( 9 ), trans-syringin ( 10 ), and citroside A ( 11 ) have been isolated from the methanol extract of the Pellionia latifolia leaves. Their chemical structures were elucidated based on extensive analyses of HR-ESI-MS, 1D and 2D NMR, and CD spectra. Compounds 1 – 7 , 9 and 10 showed moderate inhibition of NO production in LPS-activated RAW264.7 cells with their IC50 values ranging from 39.27 to 75.42 μM, compared to that of the positive control compound, dexamethasone, IC50 value of 14.20 μM. |
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| Keywords: | Pellionia latifolia pelliolatifolia A pelliolatifolia B pelliolatifolia C pelliolatifolia D |
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