A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA |
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| Authors: | Ivan Vučković Vlatka Vajs Miroslava Stanković Vele Tešević Slobodan Milosavljević |
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| Institution: | 1. Institute of Chemistry, Technology and Metallurgy, Njego?eva 12, 11000 Belgrade, Serbia;2. Physical Chemistry Laboratory, Vinca Institute of Nuclear Sciences, Belgrade, Serbia;3. Faculty of Chemistry, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia, (phone: +381?11?2630?474;4. fax: +381?11?2636?061) |
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| Abstract: | A new prenylated flavanonol named seselinonol ( 1 ) was isolated from the roots of Seseli annuum, together with the well‐known biologically active polyacetylenes falcarinol ( 2 ) and falcarindiol ( 3 ), and the prenylated furanocoumarin phellopterin ( 4 ). Its structure was elucidated by extensive spectroscopic analysis, including HR‐ESI‐MS, 1D‐ and 2D‐NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin‐B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes. |
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| Keywords: | Seseli annuum Flavanonols Polyacetylenes Seselinonol Falcarinol Falcarindiol Phellopterin DNA Protective activity |
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