Improvement of Metabolic and Histological Changes of Adiposity in Rats by Synthetic Oleoyl Chalcones |
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| Authors: | Azza A M AlKhathami Hosam A Saad Fareed A Fareed Eman S El-Shafey Eslam S Elsherbiny Mamdouh R El Nahas Mohamed R E Aly |
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| Institution: | 1. Department of Chemistry, College of Science, Taif University, P. O. Box 11099, Taif, 21944 Saudi Arabia;2. Department of Chemistry, College of Science, Taif University, P. O. Box 11099, Taif, 21944 Saudi Arabia
Chemistry Department, Faculty of Science, Zagazig University, 44511 Zagazig, Egypt;3. Chemistry Department, Faculty of Science, Port Said University, 42522 Port Said, Egypt, on leave from Taif University to Port Said University;4. Biochemistry Department, Faculty of Science, Damietta University, 34517 Damietta, Egypt;5. Internal Medicine Department, Faculty of Medicine, Port Said University, 42522 Port Said, Egypt |
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| Abstract: | We previously reported that synthetic oleoyl chalcones had a favorable effect to alleviate metabolic consequences of obesity in male SD rats. In this work, we prepared and characterized by spectroscopic tools, a set of six oleoyl chalcones ( 5a–c , 10 and 11a,b ). The comparative effects of the previously prepared oleoyl chalcones and their new synthetic analogs on metabolic and histological changes in obese male SD rats were studied. It was found that the oleoyl chalcones IIIa and IV were the best in improving many metabolic parameters, e. g., FBG, FI, ISI, TG, and total cholesterol. They cured systemic inflammation, through inhibition of the TNF-α and induction of adiponectin production. Moreover, chalcones IIIa and IV alleviated the oxidative stress accompanying obesity through the induction of the antioxidant enzymes GPX, SOD and CAT besides, GSH. Interestingly, chalcones IIIa and IV exerted hepatoprotective potency and ameliorated the manifestations of NAFLD via inhibition of apoptosis and induction of autophagy of hepatic cells. In conclusion, the oleoyl chalcones IIIa and IV were the most effective candidates among the series of synthetic chalcones in correcting body weight and the consequent metabolic and histological changes in adiposity. |
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| Keywords: | oleoyl chalcones antiobesity anti-inflammatory antioxidant hepatoprotection |
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