| Institution: | 1. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, P. R. China;2. Yibin Institute of Southwest Jiaotong University, Yibin, Sichuan, 644000 P. R. China;3. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, P. R. China
Yibin Institute of Southwest Jiaotong University, Yibin, Sichuan, 644000 P. R. China |
| Abstract: | Four new aconitine-type C19-diterpenoid alkaloids, were isolated from the roots of Aconitum nagarum Stapf which were named as nagarutines A–D ( 1–4 ), together with eleven known compounds ( 5–15 ). The structures of the compounds were identified by IR, HR-ESI-MS, 1D and 2D NMR spectra. All compounds were tested for the inhibitory effect on LPS induced NO production in RAW 264.7 macrophages, compound 7 showed moderate anti-inflammatory activity effect and Inhibition rate is about 44.50%. |
