Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection |
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| Authors: | Miroslav Novakovi? Miroslava Stankovi? Ivan Vu?kovi? Nina Todorovi? Sne?ana Trifunovi? Danijela Apostolovi? Boris Mandi? Milan Velji? Petar Marin Vele Te?evi? Vlatka Vajs Slobodan Milosavljevi? |
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| Institution: | 1. Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Studentski trg 16, RS‐11000 Belgrade (phone: +381‐11‐2630474;2. fax: +381‐11‐2636061);3. Faculty of Chemistry, University of Belgrade, Studentski trg 16, RS‐11000 Belgrade;4. Faculty of Biology, University of Belgrade, Studentski trg 16, RS‐11000 Belgrade |
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| Abstract: | Nine diarylheptanoids, 1 – 9 , catechin ( 11 ), and a phenolic glucoside, 10 , were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10 , are new. The structures of 1 – 11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis‐block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine. |
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| Keywords: | Green alder Heptanoids diaryl‐ Cytokinesis‐block micronucleus (CBMN) assay |
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