Bioactive Coumarins from the Stems of Clausena emarginata |
| |
| Authors: | Guo‐Qing Ouyang Chuang‐Jun Li Jing‐Zhi Yang Li Li Xiu‐Yun Song Yi‐Na Jiang Nai‐Hong Chen Jie Ma Dong‐Ming Zhang |
| |
| Institution: | 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China;2. +86‐10‐60212113;3. +86‐10‐63165227+86‐10‐63165227 |
| |
| Abstract: | Five new coumarins, clauemarmarins I – M ( 1 – 4 ), together with 10 known analogs ( 5 – 14 ), were isolated from the stems of Clausena emarginata. Compounds 8 – 13 were obtained from this plant for the first time. Their structures were established and elucidated by comprehensive analysis of spectroscopic data. The absolute configurations of 1 – 4 were further determined by their electronic circular dichroism spectroscopy. Compounds 5 , 7 , 12 , and 14 exhibited inhibitory effects on LPS‐induced NO production. Compounds 5 – 7 showed selective neuroprotective effects in Aβ25 – 35 model at 10 μm . |
| |
| Keywords: | Clausena emarginata Stems Clauemarmarins Neuroprotective effects Inhibitory effects |
|
|
