Hydrolysis and cytotoxic properties of osmium(II)/(III)-DMSO-azole complexes. Short communication |
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| Authors: | Egger Alexander Cebrián-Losantos Berta Stepanenko Iryna N Krokhin Artem A Eichinger Rene Jakupec Michael A Arion Vladimir B Keppler Bernhard K |
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| Institution: | 1. University of Vienna, Institute of Inorganic Chemistry, W?hringerstrasse 42, A‐1090 Vienna, (phone: +43‐1‐4277‐52600;2. fax: +43‐1‐4277‐9526) |
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| Abstract: | The antiproliferative properties of the osmium(II) complexes cis,fac-Os(II)Cl(2)(DMSO)(3)(L)] and trans,cis,cis-Os(II)Cl(2)(DMSO)(2)(L)(2)] (L = 1H-pyrazole, 1H-imidazole) were studied in three human cancer cell lines, namely 41M (ovary), SK-BR-3 (breast), and SW480 (colon). Their activities were compared with those of osmium(III) and ruthenium(III) NAMI-A type complexes on HT-29 (colon) and SK-BR-3 cancer cell lines. While IC(50) values of all the Os(II) complexes were found to be >1000 microM in all cell lines, Os and Ru-NAMI-A type complexes showed remarkable antiproliferative activity. The marginal in vitro cytotoxicity of the Os(II) compounds is presumably attributed to their resistance to hydrolysis. However, the Os-NAMI-A complexes, which are also kinetically stable in aqueous solution, showed reasonable antiproliferative activity in vitro when compared with the analogous Ru compounds and with the Os(II)-DMSO-azole species, indicating that hydrolysis might be not a prerequisite for the antitumor activity of Os-NAMI-A type complexes. |
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| Keywords: | Ruthenium complexes Osmium complexes Cytotoxic activity Hydrolysis Anticancer activity |
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