Two new megastigmane glycosides, physanosides A and B, from Physalis alkekengi L. var. franchetii, and their effect on NO release in macrophages |
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Authors: | Qiu Li Zhao Feng Liu Hongwei Chen Lixia Jiang Zhihu Liu Hongxia Wang Naili Yao Xinsheng Qiu Feng |
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Institution: | Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University 81#, No. 103 Road WenHua, Shenyang 110016, PR China. |
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Abstract: | Two new megastigmane glycosides, physanosides A and B (1 and 2, resp.), were isolated from Physalis alkekengi L. var. franchetii, together with four known compounds (6S,9R)-roseoside (3), (6S,9S)-roseoside (4), (6R,9S)-3-oxo-alpha-ionol beta-D-glucopyranoside (5), and citroside A (6). Their structures were elucidated on the basis of physicochemical evidence, in-depth NMR spectroscopic analysis, high-resolution mass spectrometry, and CD spectroscopy, and their inhibitory effect on NO production was also examined. Compounds 2 and 3 exhibited strong inhibition on lipopolysaccharide-induced NO release by macrophages with IC(50) values of 9.93 and 7.31 microM, respectively. |
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Keywords: | Megastigmane glycosides Glycosides Physanosides A and B Physalis alkekengi Inhibitors Macrophages NO Release |
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