Four New Triterpenoid Saponins from the Root of Ilex centrochinensis |
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| Authors: | Hang Yang Yan-Xia Lu Yu Shi Xue-Ying Deng Ying-Tao Yi Lu-Jun Li Ze-Hua Hu |
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| Institution: | 1. National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Bio-technology of Traditional Chinese Medicine, Hubei University, Wuhan, 430062 China;2. Medical School, Hubei University for Nationalities, Enshi Tujiazumiaozuzizhizhou, Enshi, 445000 China |
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| Abstract: | One new siaresinolic acid saponin ( 1 ) and three new rotundic acid saponins ( 2 – 4 ) were isolated from the roots of Ilex centrochinensis. Their structures were confirmed by detailed analysis of standard spectroscopic data (IR, MS, 1D and 2D NMR). Compounds 1 – 4 exhibited anti-inflammatory activity by inhibiting nitric oxide production in a lipopolysaccharide-induced RAW264.7 cell inflammatory model. However, they showed no significant lipid-lowering activity against the production of triglycerides in the lipid-accumulation model of HepG2 cells induced by oleic acid. |
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| Keywords: | Ilex centrochinensis triterpenoid saponins structural elucidation anti-inflammatory activity |
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