Two New Prenylated Indole Diterpenoids from Tolypocladium sp. and Their Antimicrobial Activities |
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Authors: | LuLin Xu Xue‐Jiao Pang Qiong Shi Peng‐Jie Xian Yan‐Duo Tao Xiao‐Long Yang |
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Institution: | Lu–Lin Xu,Xue‐Jiao Pang,Qiong Shi,Peng‐Jie Xian,Yan‐Duo Tao,Xiao‐Long Yang |
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Abstract: | Two new prenylated indole diterpenoids, tolypocladins K and L ( 1 and 2 ), together with a known analog terpendole L ( 3 ), were isolated from the solid fermentation culture of a mine soil‐derived fungus Tolypocladium sp. XL115. Their structures and relative configurations were determined by comprehensive spectroscopic data analysis, as well as by comparison of their NMR data with those related known compounds. Compound 3 exhibited remarkable antibacterial activity against Micrococcus luteus with an MIC value of 6.25 μg/mL, and compounds 1 and 3 displayed moderate antifungal activity selectively against tested strains with MIC values of 25–50 μg/mL. |
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Keywords: | Tolypocladium indole diterpenoid antimicrobial activity biological activity phytochemistry |
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