The genetics of kidney transplantation |
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Authors: | Nicolas Pallet Eric Thervet |
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Institution: | 1.INSERM U775, Centre Universitaire des Saints Pères,Université Paris Descartes,Paris,France;2.Service de Néphrologie, H?pital Européen Georges Pompidou,Université Paris Descartes,Paris,France |
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Abstract: | Over the last decade, the search for gene variants with the potential to influence transplant outcomes or predispose individuals
to host–recipient-related phenotypes has generated a considerable number of studies with conflicting results. Thousands of
genotypes have been associated with complex traits related to transplant medicine, including acute rejection, immunosuppressive
drug metabolism and side effects, infections, long-term outcomes, and cardiovascular complications. However, these efforts
have given disappointing results, both in terms of gaining understanding of the biological basis of disease and in patient
management. The methodological weaknesses that constitute the major limitations of most of these studies have been discussed
widely. A new generation of approaches is needed to understand the relationship between gene variants and complex kidney transplantation
traits. These approaches should be global, to generate original pathophysiological hypotheses, and should rely on advanced
genomic tools, including Genome Wide Association studies and Whole Genome Sequencing technologies. Such enterprises will only
be successful with the creation of international consortiums that connect partners in clinical, industrial, and academic transplant
medicine. |
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Keywords: | |
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