Analysis of synaptonemal complexes in a heterozygous human male carrier of a reciprocal translocation involving an acrocentric chromosome: heterosynapsis without previous homosynapsis |
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Authors: | A de Perdigo O Gabriel-Robez Y Rumpler |
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Institution: | (1) Institut d'Embryologie, Faculté de Médecine, Université Louis Pasteur, 11, Rue Humann, F-67085 Strasbourg, France |
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Abstract: | Summary Silver-stained synaptonemal complexes in surface-spread pachytene nuclei from an oligospermic man, heterozygous for a reciprocal translocation involving an acrocentric chromosome, were analyzed by electron microscopy. Contrary to the classically expected configuration, nonhomologous pairing was observed with asymetrical association of the lateral elements of the nonhomologous arms of the quadrivalents. A possible role of heterosynapsis in germ cell conservation is discussed. |
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