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Screening of the C677T mutation on the methylenetetrahydrofolate reductase gene in French patients with neural tube defects |
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| Authors: | E Mornet Françoise Muller Annie Lenvoisé-Furet Anne-Lise Delezoide Jean-Yves Col Brigitte Simon-Bouy Jean-Louis Serre |
| Institution: | Laboratoire de Cytogénétique et Génétique Moléculaire Humaine, Université de Versailles-Saint Quentin, 45 Avenue des Etats-Unis, F-78035 Versailles Cedex, France Tel.: (33) 01 39 25 46 76; Fax: (33) 01 39 25 46 78 e-mail: Etienne.Mornet@cytogene.uvsq.fr, FR Unité de Foetopathologie, H?pital Necker-Enfants Malades, Paris, France, FR Gynécologie Obstétrique, Centre Hospitalier du Havre, Le Havre, France, FR Centre d’Etudes de Biologie Prénatale – SESEP, Université de Versailles-Saint Quentin, Versailles, France, FR |
| Abstract: | We report the analysis of the distribution of the C677T mutation on the methylenetetrahydrofolate reductase (MTHFR) gene in prenatally diagnosed neural tube defects (NTD) cases and controls. In contrast to previous reports, we found the same distribution in fetuses with NTD and controls, which suggests that the MTHFR C677T mutation cannot be regarded as a genetic risk factor for NTD. Received: 23 April 1997 / Accepted: 28 May 1997 |
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