ACP1 and human adaptability 2. Association with season of conception |
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Authors: | Fulvia Gloria-Bottini Nazzareno Lucarini Ricciotti Palmarino Mauro La Torre A Amante E Bottini |
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Institution: | (1) Università di Roma Tor Vergata, Dipartimento di Chirurgia, Cattedra di Pediatria Preventiva e Sociale, Via di Tor Vergata, 135, I-00173 Rome, Italy Tel.: +39-6-72596030; Fax: +39-6-72596028, IT;(2) Department of Molecular, Cellular, Animal Biology, University of Camerino, School of Science, Camerino, Italy, IT;(3) Center for Evolutionary Genetics, National Research Council, University of Rome La Sapienza, Rome, Italy, IT;(4) Department of Pediatrics, Local Socio-Sanitary Unit, Penne, Italy, IT |
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Abstract: | We have studied the pattern of association between the season of conception and cytosolic low molecular weight phosphotyrosine
phosphatase (ACP1) genetic polymorphism in 329 consecutively newborn infants from the population of Penne and 361 consecutively
newborn infants from the population of Rome. In addition, 329 mothers were studied in the population of Penne. A concordant,
highly significant association was observed in the two populations between ACP1 parameters and the season of conception of
newborn infants. The total activity of ACP1 shows a minimum in infants conceived in January–February and a maximum in those
conceived at the end of the solar year. Analysis of the joint mother-newborn ACP1 distribution in relation to the season of
fertilisation has shown that among mothers carrying ACP1*A (the allele showing the lowest activity), the proportion of newborns
carrying this allele is higher in those conceived in the first months of the year than in those conceived subsequently. Since
ACP1 probably functions as a phosphotyrosine phosphatase and as a flavin mononucleotide phosphatase, low activity could enhance
the metabolic rate and would be advantageous in a cold environment. The cycle of variation of ACP1 in infants follows the
cycle of solar illumination. It is possible that individuals who have a genetic background allowing them to adapt easily and
readily to seasonal demand are more successful in reproducing themselves. The population of zygotes conceived in a given season
would therefore reproduce the pattern of gene combination more fit for that season.
Received: 15 June 1997 / Accepted: 31 July 1997 |
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