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Mapping of the gene encoding the B56β subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1) |
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| Authors: | S A Forbes A A J Pannett J H D Bassett B Harding C Wooding R V Thakker R Butler D Ogilvie R Anand P Gaudray G Weber C Larsson C X Zhang A Calender J W M Höppener C J M Lips K Kas |
| Institution: | MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK Tel.: +44 181 383 3014; Fax: + 44 181 383 8306 e-mail: rthakker@rpms.ac.uk, GB Zeneca Pharmaceuticals Plc, Mereside, Alderly Park, Macclesfield, Cheshire, SK10 4TG, UK, GB Instabilité et altérations des génomes, UNSA/CNRS UMR 6549, Avenue de Valombrose F-06107 Nice, France, FR Department of Molecular Medicine, CMM, Karolinska Hospital, L8: 01, S-171 76 Stockholm, Sweden, SE Service de Génétique, Pavillon E, H?pital Edouard Herriot, Place d’Arsonval, F-69437 Lyon cedex 03, France, FR Department of Pathology, Utrecht University Hospital, H04-312, PO Box 05500, Heidelberglaan 100, NL-3508 GA Utrecht, The Netherlands, NL Laboratory for Molecular Oncology, Centre for Human Genetics, K U Leuven, Herestraat 49, B-3000 Leuven, Belgium, BE |
| Abstract: | The multiple endocrine neoplasia type 1 (MEN1) locus has been previously localised to 11q13 by combined tumour deletion mapping and recombination studies, and a 0.5-Mb region, flanked by PYGM and D11S449, has been defined. In the course of constructing a contig, we have identified the location of the gene encoding the B56β subunit of protein phosphatase 2A (PP2A), which is involved in cell signal transduction pathways and thus represents a candidate gene for MEN1. We have searched for mutations in the PP2A-B56β coding region, together with the 5′ and 3′ untranslated regions in six MEN1 patients. DNA sequence abnormalities were not identified and thus the PP2A-B56β gene is excluded as the candidate gene for MEN1. However, our precise localisation of PP2A-B56β to this region of 11q13 may help in elucidating the basis for other disease genes mapping to this gene-rich region. Received: 17 April 1997 / Accepted: 22 April 1997 |
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