Repeated DNA sequences in the distal long arm of the human X chromosome |
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Authors: | U Müller U Tantravahi A Monaco Helene Stroh L M Kunkel S A Latt |
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Institution: | (1) Genetics Division and Mental Retardation Center, Children's Hospital, 300 Longwood Avenue, 02115 Boston, MA, USA;(2) Department of Pediatrics, Harvard Medical School, 02115 Boston, MA, USA;(3) Department of Genetics, Harvard Medical School, 02115 Boston, MA, USA;(4) Department of Neuroscience, Harvard Medical School, 02115 Boston, MA, USA |
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Abstract: | Summary Two DNA probes from within a single large insert from a recombinant phage-DNA library that was constructed from flow-sorted chromosomes enriched for the human X chromosome were shown to hybridize with repeated X-specific and autosomal DNA sequences. The X-chromosomal repeated sequences were assigned to the distal long arm of the X chromosome by both hybrid mapping and in situ hybridization. Fine mapping places these repeats in a region of Xq28 between DX13 (DXS15, in distal Xq28) and factor VIII (F8C, in proximal Xq28). The location of the X-specific repeats makes them potentially useful for future investigations of discases mapping to the distal long arm of the X chromosome, such as the fragile X syndrome. |
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