| 源于植物内生无花果拟盘多毛孢真菌的新色原酮类次生代谢产物研究 |
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| 引用本文： | 刘述春,刘玲.源于植物内生无花果拟盘多毛孢真菌的新色原酮类次生代谢产物研究[J].菌物学报,2010,29(4):582-587. |
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| 作者姓名： | 刘述春 刘玲 |
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| 作者单位： | 中国科学院微生物研究所真菌地衣系统学重点实验室,北京,100190 |
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| 基金项目： | 国家自然科学基金（No. 30870057） |
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| 摘 要： | 从植物内生真菌无花果拟盘多毛孢菌株(Pestalotiopsis fici;AS3.9138=W106-1)的放大发酵粗提物中分离得到4个异戊二烯基取代的色原酮类新结构次生代谢产物pestaloficiolsM-P(1-4),并应用质谱和核磁共振技术确定了上述化合物的结构。生物活性测试结果表明化合物2能够抑制HIV-1病毒在C8166细胞中的复制;化合物3和4对宫颈癌细胞(HeLa)具有细胞毒活性;另外,化合物3对烟曲霉Aspergillus fumigatus也具有较强的抑制活性。
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| 关 键 词： | 植物内生真菌 新色原酮类化合物 生物活性 |
Isoprenylated chromones from the plant endophytic fungus Pestalotiopsis fici |
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| Authors: | LIU Shu-Chun and LIU Ling |
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| Institution: | Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China;Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China |
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| Abstract: | Pestaloficiols M-P(1-4),new isoprenylated chromone derivatives,have been isolated from a scale-up fermentation extract of the plant endophytic fungus Pestalotiopsis fici.The structures of these compounds were elucidated primarily by MS and NMR techniques.Compound 2 displayed inhibitory effects on HIV-1 replication in C8166 cells,whereas compounds 3 and 4 showed cytotoxic activity against the human tumor cell line HeLa.Compound 3 also showed antifungal activity against Aspergillus fumigatus. |
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| Keywords: | endophytic fungi new chromones bioactivity |
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