分泌型蛋白介导白念珠菌与宿主相互作用分子机制的研究进展

白念珠菌是人类最常见的条件性致病真菌之一,主要定植于人体粘膜表面。在白念珠菌与宿主相互作用过程中,分泌型蛋白起着非常重要的作用。针对分泌蛋白功能及其作用机理的研究有助于阐明白念珠菌致病分子机制,并为诊断、预防和治疗真菌感染提供新的理论策略。本文综述了白念珠菌分泌型蛋白在介导病原与宿主相互作用分子机制方面的最新研究进展,概括了分泌蛋白在组织侵入损伤、营养获取、细胞壁维持以及免疫逃避等方面的功能,同时对未来值得重点关注的研究方向进行了探讨。

Research advances of secreted proteins in mediating the interaction between host and the fungal pathogen Candida albicans

Candida albicans is one of the most common opportunistic human fungal pathogens and mainly colonizes on the surface of human mucosa. It has been appreciated that secreted proteins of C. albicans play vital roles in mediating the interactions of this fungus with the host. Understanding the functions and action modes of secreted proteins will greatly benefit the study of pathogenesis of C. albicans and provides novel strategies for diagnosis, prevention and treatment of fungal infections. In this review, we describe the latest progresses in studying the secreted proteins in C. albicans and summarize their functions in tissue invasion, nutrient acquisition, cell wall maintenance and immune evasion when the fungus meets with the host. A few major directions that may gain more insights into this area is proposed.