富硒发酵毛头鬼伞菌丝对四氧嘧啶致糖尿病小鼠抗氧化和降血糖的影响

本文研究了富硒发酵毛头鬼伞(鸡腿菇)Coprinus comatus菌丝体对四氧嘧啶致糖尿病小鼠抗氧化和降血糖的影响。四氧嘧啶建立糖尿病小鼠模型后,将富硒发酵毛头鬼伞菌丝均匀混入饲料中,由小鼠自由取食进行治疗,3周后观察富硒毛头鬼伞菌丝对糖尿病小鼠血糖、MDA、SOD和GSH-Px的影响。结果发现,采用富硒发酵毛头鬼伞菌丝进行治疗后,糖尿病小鼠血糖明显降低;血清和组织中MDA含量显著下降;血清和组织中的SOD和GSH-Px的活力明显的增加。由此推断,富硒发酵毛头鬼伞菌丝对四氧嘧啶致糖尿病小鼠的降血糖效果可能是通过提高机体抗氧化能力来实现的。

Selenium-enriched fermentation mycelia of Coprinus comatus enhance the antihyper- glycemia and antioxidant activities in alloxan-induced diabetic mice

This study evaluated the effect of selenium-enriched fermentation mycelia of C. comatus (SMCC) on reducing oxidative stress and hyperglycemia in alloxan-induced diabetic mice. After induction of diabetes, a significant increase of the levels of blood glucose and lipid peroxidation associated with the diminution of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) was observed in all diabetic mice. Treatment of diabetic mice with SMCC for 21 days resulted in a significant reduction in blood glucose and the injuries of pancreas. In addition, a significant increase in the activities of SOD and GSH-Px and a significant decrease in the content of malondialdehyde (MDA) were observed in serum, liver and kidney. The results showed that SMCC might be able to inhibit hyperglycemia, and helpful in the prevention of diabetic complications associated with oxidative damage. It is concluded that SMCC possesses potent antioxidant activity, which may be directly or indirectly responsible for inhibiting hyperglycemia of alloxan-induced diabetic mice.