系统发育研究中直同源预测方法的选择策略

测序技术的不断发展和价格的日益降低使得系统发育组学更深层次的研究成为可能。在系统发育组学分析中,至关重要的步骤是直同源预测,这是因为进行系统发育重建的先决条件是进行比对的基因是直同源的。这里我们简单地回顾了直同源的定义和直同源预测的不同方法,与此同时,我们还给出了一些选择更合适的直同源预测方法的建议。

A brief review on the strategy for selection of orthology prediction methods in phylogenomic studies

With the development and decreasing cost of sequencing techniques, it is possible for scientists to conduct deeper research in phylogenomics. During the procedure of phylogenomic analysis, the most important and vitalest step is orthology prediction, for that the prerequisite to phylogenetic reconstruction is that the genes being compared are orthologous. Here we briefly review the related concept of orthology and different methods for orthology prediction. We also provide recommendations to give some advice for better selection of orthology prediction methods.