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Azadirone,a Limonoid Tetranortriterpene,Induces Death Receptors and Sensitizes Human Cancer Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) through a p53 Protein-independent Mechanism: EVIDENCE FOR THE ROLE OF THE ROS-ERK-CHOP-DEATH RECEPTOR PATHWAY* |
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| Authors: | Subash C Gupta Sajin K Francis Mangalam S Nair Yin-Yuan Mo Bharat B Aggarwal |
| Institution: | From the ‡Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.;the ¶Organic Chemistry Section, National Institute for Interdisciplinary Science and Technology (CSIR), Trivandrum, 695 019 Kerala, India, and ;the §Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216 |
| Abstract: | |
| Keywords: | Anticancer Drug Apoptosis Cancer Therapy MAP Kinases (MAPKs) Reactive Oxygen Species (ROS) Trail CHOP Death Receptor Limonoid |