Production of Hydrophobins from fungi |
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Institution: | 1. Institut des Matériaux Jean Rouxel, Université de Nantes, 2 rue de la Houssinière, 44322 Nantes Cedex 3, France;2. Université d''Angers, UMR 1345 IRHS, SFR QUASAV, 2 Bd Lavoisier, Angers cedex F-49045, France;3. Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire d''Angers, France;4. L''UNAM Université, Université d''Angers, Groupe d''Etude des Interactions Hôte-Pathogène, UPRES-EA 3142, Angers, France |
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Abstract: | Hydrophobins (HPs) are industrially important surface active, amphipathic proteins produced by fungi. There are many applications reported for HPs in the literature notably as, agents for enhancing bioavailability of water insoluble drugs, food stabilizers, antifouling agents for biomedical devices like catheters, fusion partner for recombinant proteins for purification, low friction coatings on biomaterials, immobilizing enzymes in biosensors, etc. However, there are limitations for industrial scale production of HPs. Various methods have been reported for their production e.g. use of wild fungi from natural hydrophobic environments, use of modified bioreactors for submerged and solid state fermentation and recombinant homologous as well as heterologous microbes. Knowing the industrial importance of HPs many reviews have been published focusing on technical and medical applications of these proteins; however there is no comprehensive overview of HP production in the literature. This review summarizes the efforts made to improve yields of HPs by various bioprocesses and also highlights the strategies designed to overcome problems of low yield of HPs. |
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Keywords: | Hydrophobins Ascomycetes Basidiomycetes Fermentation |
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