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Multiplexed,rapid detection of H5N1 using a PCR-free nanoparticle-based genomic microarray assay |
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| Authors: | Jiangqin Zhao Shixing Tang James Storhoff Sudhakar Marla Y Paul Bao Xue Wang Eric Y Wong Viswanath Ragupathy Zhiping Ye Indira K Hewlett |
| Institution: | (1) Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA;(2) Nanosphere Inc., 4088 Commercial Avenue, Northbrook, IL 60062, USA;(3) Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA |
| Abstract: | BackgroundFor more than a decade there has been increasing interest in the use of nanotechnology and microarray platforms for diagnostic applications. In this report, we describe a rapid and simple gold nanoparticle (NP)-based genomic microarray assay for specific identification of avian influenza virus H5N1 and its discrimination from other major influenza A virus strains (H1N1, H3N2). |
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