(1) Department of Physiology, , 6-125 Jackson Hall, 321 Church St, S. E., Minneapolis, MN 55455, USA
Abstract:
Background
A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific solutes, required specification of a large number of parameters and have not been designed for general use.