Comparative genomics reveals 104 candidate structured RNAs from bacteria,archaea, and their metagenomes |
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| Authors: | Zasha Weinberg Joy X Wang Jarrod Bogue Jingying Yang Keith Corbino Ryan H Moy Ronald R Breaker |
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| Institution: | (1) Howard Hughes Medical Institute, Yale University, P.O. Box 208103, New Haven, CT 06520-8103, USA;(2) Department of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, CT 06520-8103, USA;(3) Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208103, New Haven, CT 06520-8103, USA;(4) Department of Biology, University of Rochester, Rochester, NY 14627, USA;(5) School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA |
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| Abstract: | Background Structured noncoding RNAs perform many functions that are essential for protein synthesis, RNA processing, and gene regulation.
Structured RNAs can be detected by comparative genomics, in which homologous sequences are identified and inspected for mutations
that conserve RNA secondary structure. |
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