The reaction of the mutagen 1,1′-hexamethylene-bis[(5-p-chlorophenyl)-biguanide] with guanosine and cysteine |
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Authors: | Beate Ackermann-Schmidt Roland Süssmuth Franz Lingens |
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Abstract: | The mutagen 1,1′-hexamethylene-bis(5-p-chlorophenyl)-biguanide] reacts at 37°C with guanosine and guanine to yield xanthosine or xanthine and oxidizes cysteine to cystine. After treatment of a guanosine-labelled DNA sample from Escherichia coli with the mutagen xanthine could be detected as a reaction product. At a slow rate the mutagen is hydrolysed spontaneously yielding urea, 1,6-hexanediol and 4-chloroaniline. The reaction mechanisms both of the hydrolysis and of the reaction with cysteine and guanosine are discussed. |
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Keywords: | Mutagen Guanosine Guanine Cysteine Mutation frequency |
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