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Phylogenetic analysis of the mammalian Hoxc8 non-coding region |
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| Authors: | Kim Chang-Bae Shashikant Cooduvalli S Sumiyama Kenta Wang Wayne CH Amemiya Chris T Ruddle Frank H |
| Institution: | (1) Department of Molecular, Cellular, and Developmental Biology, Yale University, PO Box 208103, New Haven, CT 06520, USA;(2) Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology, Taejon, 305–333, Korea;(3) Department of Dairy and Animal Science, College of Agricultural Sciences, The Pennsylvania State University, 324 Henning Building, University Park, PA 16802–3503, USA;(4) Present address: Department of Molecular Genetics, Virginia Mason Research Center, 1201 9th Avenue, Seattle, WA 98101, USA |
| Abstract: | The non-coding intergenic regions of Hox genes are remarkably conserved among mammals. To determine the usefulness of this sequence for phylogenetic comparisons, we sequenced an 800-bp fragment of the Hoxc9–Hoxc8 intergenic region from several species belonging to different mammalian clades. Results obtained from the phylogenetic analysis are congruent with currently accepted mammalian phylogeny. Additionally, we found a TC mini satellite repeat polymorphism unique to felines. This polymorphism may serve as a useful marker to differentiate between mammalian species or as a genetic marker in feline matings. This study demonstrates usefulness of a comparative approach employing non-coding regions of Hox gene complexes. |
| Keywords: | comparative genomics Hox genes mammalian phylogeny Hox genes mammalian phylogeny |
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