(1) Department of Tumor Biology, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway;(2) Department of Molecular Biosciences, University of Oslo, Oslo, Norway;(3) Faculty of Medicine, University of Oslo, Oslo, Norway
Abstract:
Background
Microarray-based comparative genomic hybridisation (array CGH) is a technique by which variation in relative copy numbers
between two genomes can be analysed by competitive hybridisation to DNA microarrays. This technology has most commonly been
used to detect chromosomal amplifications and deletions in cancer. Dedicated tools are needed to analyse the results of such
experiments, which include appropriate visualisation, and to take into consideration the physical relation in the genome between
the probes on the array.