The effects of multiple features of alternatively spliced exons on the KA/KSratio test |
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Authors: | Feng-Chi Chen and Trees-Juen Chuang |
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Institution: | (1) Genomics Research Center, Academia Sinica, Academia Road, Nankang, Taipei, 11529, Taiwan;(2) Division of Biostatistics and Bioinformatics, National Health Research Institute, Miaoli County 350, Taiwan |
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Abstract: | Background The evolution of alternatively spliced exons (ASEs) is of primary interest because these exons are suggested to be a major
source of functional diversity of proteins. Many exon features have been suggested to affect the evolution of ASEs. However,
previous studies have relied on the K
A
/K
S
ratio test without taking into consideration information sufficiency (i.e., exon length > 75 bp, cross-species divergence
> 5%) of the studied exons, leading to potentially biased interpretations. Furthermore, which exon feature dominates the results
of the K
A
/K
S
ratio test and whether multiple exon features have additive effects have remained unexplored. |
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Keywords: | |
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