An integrated Bayesian analysis of LOH and copy number data |
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| Authors: | Paola MV Rancoita Marcus Hutter Francesco Bertoni Ivo Kwee |
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| Institution: | 1.Istituto Dalle Molle di Studi sull'Intelligenza Artificiale (IDSIA),Manno-Lugano,Switzerland;2.Laboratory of Experimental Oncology,Oncology Institute of Southern Switzerland (IOSI),Bellinzona,Switzerland;3.Dipartimento di Matematica,Università degli Studi di Milano,Milano,Italy;4.RSISE, ANU and SML, NICTA,Canberra,Australia |
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| Abstract: | Background Cancer and other disorders are due to genomic lesions. SNP-microarrays are able to measure simultaneously both genotype and
copy number (CN) at several Single Nucleotide Polymorphisms (SNPs) along the genome. CN is defined as the number of DNA copies,
and the normal is two, since we have two copies of each chromosome. The genotype of a SNP is the status given by the nucleotides
(alleles) which are present on the two copies of DNA. It is defined homozygous or heterozygous if the two alleles are the
same or if they differ, respectively. Loss of heterozygosity (LOH) is the loss of the heterozygous status due to genomic events. |
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