Genome-wide analysis of core promoter elements from conserved human and mouse orthologous pairs |
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| Authors: | Victor X Jin Gregory AC Singer Francisco J Agosto-Pérez Sandya Liyanarachchi Ramana V Davuluri |
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| Institution: | (1) Human Cancer Genetics Program, Comprehensive Cancer Center, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA |
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| Abstract: | Background The canonical core promoter elements consist of the TATA box, initiator (Inr), downstream core promoter element (DPE), TFIIB
recognition element (BRE) and the newly-discovered motif 10 element (MTE). The motifs for these core promoter elements are
highly degenerate, which tends to lead to a high false discovery rate when attempting to detect them in promoter sequences. |
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