The topology of metabolic isotope labeling networks |
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Authors: | Michael Weitzel Wolfgang Wiechert Katharina Nöh |
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Institution: | 1.Department of Simulation,University of Siegen,Siegen,Germany;2.Institute of Biotechnology,Research Centre Jülich,Jülich,Germany |
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Abstract: | Background Metabolic Flux Analysis (MFA) based on isotope labeling experiments (ILEs) is a widely established tool for determining fluxes
in metabolic pathways. Isotope labeling networks (ILNs) contain all essential information required to describe the flow of
labeled material in an ILE. Whereas recent experimental progress paves the way for high-throughput MFA, large network investigations
and exact statistical methods, these developments are still limited by the poor performance of computational routines used
for the evaluation and design of ILEs. In this context, the global analysis of ILN topology turns out to be a clue for realizing
large speedup factors in all required computational procedures. |
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