Modeling expression quantitative trait loci in data combining ethnic populations |
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Authors: | Ching-Lin Hsiao Ie-Bin Lian Ai-Ru Hsieh Cathy SJ Fann |
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Institution: | (1) Division of Biostatistics, Institute & Department of Public Health, National Yang-Ming University, Taipei, 112, Taiwan;(2) Department of Mathematics, National Changhua University of Education, Changhua, 500, Taiwan;(3) Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan |
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Abstract: | Background Combining data from different ethnic populations in a study can increase efficacy of methods designed to identify expression
quantitative trait loci (eQTL) compared to analyzing each population independently. In such studies, however, the genetic
diversity of minor allele frequencies among populations has rarely been taken into account. Due to the fact that allele frequency
diversity and population-level expression differences are present in populations, a consensus regarding the optimal statistical
approach for analysis of eQTL in data combining different populations remains inconclusive. |
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Keywords: | |
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