Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive responses |
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Authors: | Gonzalo Guillén-Gosálbez Albert Sorribas |
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Institution: | 1. Departament d'Enginyeria Química, Universitat Rovira i Virgili, Av.Pa?sos Catalans 26, 43007, Tarragona, Spain 2. Departament de Ciències Mèdiques Bàsiques, Institut de Recerca Biomèdica de Lleida (IRBLLEIDA), Universitat de Lleida, Montserrat Roig 2, 25008, Lleida, Spain
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Abstract: | Background Optimization methods allow designing changes in a system so that specific goals are attained. These techniques are fundamental
for metabolic engineering. However, they are not directly applicable for investigating the evolution of metabolic adaptation
to environmental changes. Although biological systems have evolved by natural selection and result in well-adapted systems,
we can hardly expect that actual metabolic processes are at the theoretical optimum that could result from an optimization
analysis. More likely, natural systems are to be found in a feasible region compatible with global physiological requirements. |
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