| 羰基生物还原法合成手性醇的研究进展 |
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| 引用本文： | 郁惠蕾,黄磊,倪燕,许国超,许建和.羰基生物还原法合成手性醇的研究进展[J].生物加工过程,2013,11(3):71-82. |
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| 作者姓名： | 郁惠蕾 黄磊 倪燕 许国超 许建和 |
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| 作者单位： | 华东理工大学生物反应器工程国家重点实验室,上海,200237 |
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| 基金项目： | 国家自然科学基金(项目编号：20902023) |
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| 摘 要： | 手性醇是合成许多光学活性药物、农用化学品及其他精细化学品的关键手性砌块。羰基生物还原法理论上可实现100%转化率,且反应条件温和,对环境十分友好,被普遍认为是生产手性醇的绿色、高效途径。综述了近年来利用生物信息学、高通量筛选和蛋白质工程的发展对新型、高效生物催化剂开发的影响,特别是利用相关技术手段开发羰基还原酶的进展。
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| 关 键 词： | 不对称还原 生物催化 羰基还原酶 手性醇 基因组挖掘 |
Advances in synthesis of chiral alcohols by carbonyl bioreduction |
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| YU Huilei
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HUANG Lei
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NI Yan
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XU Guochao
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XU Jianhe.Advances in synthesis of chiral alcohols by carbonyl bioreduction[J].Chinese Journal of Bioprocess Engineering,2013,11(3):71-82. |
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| Authors: | YU Huilei HUANG Lei NI Yan XU Guochao XU Jianhe |
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| Institution: | (State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237, China) |
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| Abstract: | Enantiopure secondary alcohols, as key intermediates, play an essential role in pharmaceutical, agrochemical, and chemical industries. Biocatalytic ketone reduction is being generally regarded as a green and effective access to enantiopure alcohols, due to mildness of reaction conditions and friendliness to environment. An increasing number of novel and robust enzymes become more easily accessible as a result of the ongoing progress in genomics, high-throughput screening, and directed evolution technologies. Advanced bioprocess engineering provide more opportunities for applying enzyme technologies to meet chiral challenges in synthetic chemistry. |
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| Keywords: | asymmetric reduction biocatalysis carbonyl reductases chiral alcohols genome mining |
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