| 菌丝空泡形态比例与青霉素合成的关系 |
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| 引用本文： | 王辉,桂芳,王鹏,刘会,蔡晓春,胡以华,郑之明.菌丝空泡形态比例与青霉素合成的关系[J].生物加工过程,2011,9(6):26-29. |
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| 作者姓名： | 王辉 桂芳 王鹏 刘会 蔡晓春 胡以华 郑之明 |
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| 作者单位： | 1. 中国科学院合肥物质科学研究院离子束生物工程重点实验室,合肥,230031
2. 解放军电子工程学院,合肥,230037 |
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| 基金项目： | 国家高技术研究发展计划(863计划)资助项目 |
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| 摘 要： | 采用图像处理技术量化菌丝空泡区域比例,并研究菌丝空泡与青霉素合成的关系.结果表明:当空泡区域比例达到20％时,青霉素开始大量合成；当空泡比例达到30％～35％时,青霉素合成最为旺盛；当空泡区域比例超过40％时,青霉素效价下降.菌丝空泡的过度膨胀是发酵进入衰退期的重要标志.
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| 关 键 词： | 空泡形态 图像处理 产黄青霉 青霉素 |
Production of penicillin from P.chrysogenum corresponding with proportions of hyphal vacuolization |
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| WANG Hui,GUI Fang,WANG Peng,LIU Hui,CAI Xiaochun,HU Yihua,ZHENG Zhiming.Production of penicillin from P.chrysogenum corresponding with proportions of hyphal vacuolization[J].Chinese Journal of Bioprocess Engineering,2011,9(6):26-29. |
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| Authors: | WANG Hui GUI Fang WANG Peng LIU Hui CAI Xiaochun HU Yihua ZHENG Zhiming |
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| Institution: | WANG Hui1,GUI Fang1,WANG Peng1,LIU Hui1,CAI Xiaochun2,HU Yihua2,ZHENG Zhiming1(1.Key Laboratory of Ion Beam Bioengineering,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China,2.Electronics Engineering Institute,Hefei 230037,China) |
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| Abstract: | An image analysis method was used to quantify hyphal vacuolization.The results showed that the production of penicillin started when proportion of vacuolated hyphae reached 20% and decreased once the proportion exceeded 40%.The highest yield was obtained when vacuolization occupied 30% to 35% of hyphae.Extensive fungal vacuoles showed decaying phase of fermentation. |
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| Keywords: | hyphal vacuolization image process P chrysogenum penicillin |
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