| 重组基因工程菌在不对称还原羰基化合物中的应用 |
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| 引用本文： | 肖美添,张亚武,黄雅燕,叶静.重组基因工程菌在不对称还原羰基化合物中的应用[J].生物加工过程,2009,7(3):1-8. |
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| 作者姓名： | 肖美添 张亚武 黄雅燕 叶静 |
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| 作者单位： | 1. 华侨大学,福建省高校工业生物技术重点实验室,厦门,361021;华侨大学,化工学院,厦门,361021
2. 华侨大学,化工学院,厦门,361021 |
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| 基金项目： | 福建省科技计划重点项目，泉州市科技计划重点项目 |
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| 摘 要： | 手性醇是药物合成的重要手性砌块，利用生物催化剂不对称还原羰基化合物是手性醇制备的重要方法。介绍了生物催化还原羰基化合物的反应原理及特点，综述了重组基因工程菌的构建及其在不对称还原羰基化合物中的应用情况，展望了今后研究发展的方向。
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| 关 键 词： | 重组基因工程菌 不对称还原 生物转化 羰基化合物 |
Application of recombinant genetic engineering strains in asymmetric reduction of carbonyl compounds |
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| XIAO Mei-tian,ZHANG Ya-wu,HUANG Ya-yan,YE Jing.Application of recombinant genetic engineering strains in asymmetric reduction of carbonyl compounds[J].Chinese Journal of Bioprocess Engineering,2009,7(3):1-8. |
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| Authors: | XIAO Mei-tian ZHANG Ya-wu HUANG Ya-yan YE Jing |
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| Institution: | XIAO Mei-tian1,2,ZHANG Ya-wu2,HUANG Ya-yan2,YE Jing2(1.Key Laboratory for Industrial Biotechnology of Fujian Province,Huaqiao University,Xiamen 361021,China,2.Institute of Chemical Engineering,China) |
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| Abstract: | Chiral alcohols are important building blocks for drug synthesis.The asymmetric reduction of carbonyl compounds with biocatalysts is an important method for producing chiral alcohols.The reaction mechanism and characteristics of asymmetric reduction of carbonyl compounds with the biocatalysts were presented.The construction of recombinant genetic engineering strains and their practical applications in the asymmetric reduction of carbonyl compounds were reviewed.The prospective of asymmetric reduction with r... |
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| Keywords: | recombinant genetic engineering strain asymmetric reduction biotransformation carbonyl compound |
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